Transformation of lamotrigine by white-rot fungus Pleurotus ostreatus

摘要: Abstract One of the most persistent pharmaceutical compounds commonly found in treated wastewater is lamotrigine (LTG). It has also been detected soils and crops irrigated with wastewater. Here we focused on ability white-rot edible mushroom Pleurotus ostreatus to remove transform LTG liquid cultures. At concentrations environmental relevance (1 10 μg L−1) was almost completely removed from culture medium within 20 days. To elucidate mechanism removal transformation, applied a physiological-based approach using inhibitors competing agent. These experiments were conducted at higher concentration for metabolites detection. Based identification sulfur-containing N2-oxide effect specific inhibitors, cytochrome P450 oxidation suggested as one reaction mechanisms leading transformation. The variety number transformation products (i.e., conjugates) current study larger than reported mammals. Moreover, known conjugates glucuronide, glutathione, or cysteine/glycine, not our system. Since majority identified LTG, this highlights persistence an organic pollutant ecosystems exposed