Management of Infections with Drug-Resistant Organisms in Critical Care: An Ongoing Battle.

作者: Sergio E. Trevino , Marin H. Kollef

DOI: 10.1016/J.CCM.2015.05.007

关键词: Critical illnessDrug resistanceCombination therapyIntensive care medicineIntensive care unitDiagnostic testMedicineCritically illAntimicrobialAnti-Infective Agents

摘要: Infections with multidrug-resistant organisms (MDROs) are common in critically ill patients and challenging to manage appropriately. Strategies that can be used the treatment of MDRO infections intensive care unit (ICU) include combination therapy, adjunctive aerosolized optimization pharmacokinetics higher doses or extended-infusion therapy as appropriate. Rapid diagnostic tests could assist improving timely appropriate antimicrobial for ICU.

参考文章(68)
Falagas Me, Michalopoulos As, Inhaled antibiotics in mechanically ventilated patients. Minerva Anestesiologica. ,vol. 80, pp. 236- 244 ,(2014)
Karri A. Bauer, Katherine K. Perez, Graeme N. Forrest, Debra A. Goff, Review of Rapid Diagnostic Tests Used by Antimicrobial Stewardship Programs Clinical Infectious Diseases. ,vol. 59, ,(2014) , 10.1093/CID/CIU547
Cristina Vazquez-Guillamet, Marin H Kollef, Treatment of gram - positive infections in critically ill patients BMC Infectious Diseases. ,vol. 14, pp. 92- 92 ,(2014) , 10.1186/1471-2334-14-92
Rosa Reina, Elisa Estenssoro, Gabriela Sáenz, Héctor S. Canales, Romina Gonzalvo, Gabriela Vidal, Gustavo Martins, Andrea Das Neves, Oscar Santander, Carlos Ramos, Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections : a prospective cohort study Intensive Care Medicine. ,vol. 31, pp. 1058- 1065 ,(2005) , 10.1007/S00134-005-2691-4
Eun Young Choi, Jin Won Huh, Chae-Man Lim, Younsuck Koh, Sung-Han Kim, Sang-Ho Choi, Yang Soo Kim, Mi-Na Kim, Sang-Bum Hong, Relationship between the MIC of vancomycin and clinical outcome in patients with MRSA nosocomial pneumonia Intensive Care Medicine. ,vol. 37, pp. 639- 647 ,(2011) , 10.1007/S00134-011-2130-7
Robert K. Pelz, Craig W. Hendrix, Sandra M. Swoboda, Marie Diener-West, William G. Merz, Janet Hammond, Pamela A. Lipsett, Double-blind placebo-controlled trial of fluconazole to prevent candidal infections in critically ill surgical patients. Annals of Surgery. ,vol. 233, pp. 542- 548 ,(2001) , 10.1097/00000658-200104000-00010
A. Bruce Montgomery, Paul R. Rhomberg, Tammy Abuan, Kathie-Anne Walters, Robert K. Flamm, Potentiation Effects of Amikacin and Fosfomycin against Selected Amikacin-Nonsusceptible Gram-Negative Respiratory Tract Pathogens Antimicrobial Agents and Chemotherapy. ,vol. 58, pp. 3714- 3719 ,(2014) , 10.1128/AAC.02780-13
Katherine K. Perez, Randall J. Olsen, William L. Musick, Patricia L. Cernoch, James R. Davis, Leif E. Peterson, James M. Musser, Integrating rapid diagnostics and antimicrobial stewardship improves outcomes in patients with antibiotic- resistant Gram-negative bacteremia Journal of Infection. ,vol. 69, pp. 216- 225 ,(2014) , 10.1016/J.JINF.2014.05.005
H. Kallel, L. Hergafi, M. Bahloul, A. Hakim, H. Dammak, H. Chelly, C. Ben Hamida, A. Chaari, N. Rekik, M. Bouaziz, Safety and efficacy of colistin compared with imipenem in the treatmentof ventilator-associated pneumonia: a matched case–control study Intensive Care Medicine. ,vol. 33, pp. 1162- 1167 ,(2007) , 10.1007/S00134-007-0675-2