Benzo[a]pyrene uptake by lymph: A possible transport mode for immunosuppressive chemicals
作者： D. L. Busbee , C. O. Joe , P. W. Rankin , R. L. Ziprin , R. D. Wilson
DOI: 10.1080/15287398409530480
关键词: Benzo(a)pyrene 、 Pharmacology 、 Lymph 、 Carcinogen 、 Biochemistry 、 Lipoprotein transport 、 Lymphatic system 、 Lipoprotein 、 Pyrene 、 Benzopyrene 、 Chemistry
摘要: Benzo[a]pyrene, a lipophilic promutagen, reached maximal concentrations in the thoracic duct lymphatic circulation within 2 h after gastric instillation. Benzo[a]pyrene lymph obtained by cannulation decreased to approximately control levels 4 treatment. When was not allowed enter blood vascular circulation, serum of benzo[a]pyrene increased very slowly, suggesting minimal mesenteric absorption hydrocarbon. partitions into lipoproteins as function lipoprotein concentration. Data suggest that low-density may take up more efficiently than do or high-density lipoproteins, and components other transport benzo[a]pyrene. We propose xenobiotic compounds interact with cells immune system via potentially mutagenic, carcinogenic, immunosuppressive agents.
sci-hub.se 参考文章(20)
R. D. Wilson, R. L. Ziprin, M. H. Elissalde, D. E. Clark, Absorption of polychlorinated biphenyl by the ovine lymphatic system. Veterinary and Human Toxicology. ,vol. 22, pp. 305- 308 ,(1980)
Theodore L. McLemore, R. Russell Martin, Robert R. Springer, Nelda P. Wray, Kenneth L. Toppell, Laurens R. Pickard, Kenneth L. Mattox, Gene A. Guinn, Elroy T. Cantrell, David L. Busbee, Analysis of aryl hydrocarbon hydroxylase activity in human lung tissue, pulmonary macrophages, and blood lymphocytes. Cancer. ,vol. 41, pp. 2292- 2300 ,(1978) , 10.1002/1097-0142(197806)41:6<2292::AID-CNCR2820410630>3.0.CO;2-2
Badri P. Maliwal, Frank E. Guthrie, Interaction of insecticides with human plasma lipoproteins. Chemico-Biological Interactions. ,vol. 35, pp. 177- 188 ,(1981) , 10.1016/0009-2797(81)90141-1
S S Alam, K A Solen, D L Layman, M C Riddle, W E Connor, The mass uptake of cholesterol ester from low density lipoproteins by cultured smooth muscle and adventitial cells of human aortas. Circulation Research. ,vol. 47, pp. 374- 383 ,(1980) , 10.1161/01.RES.47.3.374
M. S. Brown, S. E. Dana, J. L. Goldstein, Receptor dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 2925- 2929 ,(1975) , 10.1073/PNAS.72.8.2925
J. George Bekesi, John Roboz, H. A. Anderson, Julia P. Roboz, A. S. Fischbein, I. J. Selikoff, J. F. Holland, Impaired immune function and identification of polybrominated biphenyls (PBB) in blood compartments of exposed Michigan dairy farmers and chemical workers Drug and Chemical Toxicology. ,vol. 2, pp. 179- 191 ,(1979) , 10.3109/01480547908993189
R. Shireman, L. L. Kilgore, W. R. Fisher, Solubilization of apolipoprotein B and its specific binding by the cellular receptor for low density lipoprotein Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 5150- 5154 ,(1977) , 10.1073/PNAS.74.11.5150
J.C. Street, R.P. Sharma, Alteration of induced cellular and humoral immune responses by pesticides and chemicals of environmental concern: quantitative studies of immunosuppression by DDT, aroclor 1254, carbaryl, carbofuran, and methylparathion. Toxicology and Applied Pharmacology. ,vol. 32, pp. 587- 602 ,(1975) , 10.1016/0041-008X(75)90123-4
D.L. Busbee, P.W. Rankin, D.M. Payne, D.W. Jasheway, Binding of benzo[a]pyrene and intracellular transport of a bound electrophilic benzo[a]pyrene metabolite by lipoproteins. Carcinogenesis. ,vol. 3, pp. 1107- 1112 ,(1982) , 10.1093/CARCIN/3.10.1107
J G Chalmers, The adsorption of 3:4-benzpyrene and its fluorescent metabolites on serum proteins. British Journal of Cancer. ,vol. 9, pp. 320- 326 ,(1955) , 10.1038/BJC.1955.29