The effect of short- versus long-term administration of alpha tocopherol on the survival of random flaps in experimental diabetes mellitus.

摘要: The effects of short- versus long-term alpha tocopherol administration on oxidative stress and survival dorsal random flaps were studied in diabetic rats. Seven groups, with 20 rats each, constructed: (1) control, (2) noncontrolled diabetes, (3) diabetes+short-term tocopherol, (4) diabetes+long-term (5) insulin treatment, (6) insulin+short-term (7) insulin+long-term tocopherol. After 3 months McFarlane raised. Flap viability free-radical measurements histopathological examination investigated. Mean flap Groups I to VII 84.0+/-2.2%, 55.0+/-2.4%, 57.0+/-2.5%, 57.8+/-3.7%, 64.1+/-4.1%, 70.0+/-4.9%, 77.0+/-6.6%, respectively. Free-radical concentration, as assessed luminol- lucigenin-enhanced chemiluminiscence, was inversely correlated survival. results for concentrations significant between 1, 2, 5, 6, 7. Random animals showed significantly greater necrosis compared controls. Among the animals, group receiving combination treatment had greatest least tissue concentration. Histopathological studies a hyalinization arterioles diabetics protecting vessel wall. In conclusion, experimental diabetes mellitus show necrosis, which is only partially corrected treatment. Long-term antioxidant supplementation an adjunct further lowers stress, protects structure function, therefore increases