Blood Levels of Drug at the Equilibrium State after Multiple Dosing
作者： J. G. WAGNER , J. I. NORTHAM , C. D. ALWAY , O. S. CARPENTER
DOI: 10.1038/2071301A0
关键词: Fixed dose 、 Thermodynamic equilibrium 、 Blood level 、 Multiple dosing 、 Drug 、 Mathematics 、 Regimen 、 Anesthesia 、 Steady state (electronics) 、 Interval (graph theory)
摘要: … 1–20 that when a fixed dose of drug is administered in a fixed multiple-dose regimen, the blood levels of drug eventually reach a steady state in which the blood level time curve during …
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Ekkehard Kr�ger-Thiemer, Funktionale Beziehungen zwischen den pharmakokinetischen Eigenschaften und der Dosierung von Chemotherapeutica Journal of Molecular Medicine. ,vol. 38, pp. 514- 520 ,(1960) , 10.1007/BF01482679
Ekkehard Kr�ger-Thiemer, Die experimentelle Bewertung neuer Sulfanilamide als Vorbereitung ihrer klinischen Prüfung Journal of Molecular Medicine. ,vol. 40, pp. 153- 158 ,(1962) , 10.1007/BF01482019
T. B. Binns, Absorption and distribution of drugs E. & S. Livingstone. ,(1964)
Ekkehard Krüger-Thiemer, Dosage Schedule and Pharmacokinetics in Chemotherapy * *Received August 26, 1959, from the Tuberkuloseforschungsinstitut Borstel, Borstel bei Bad Oldesloe, Holstein, Bundesrepublik, Western Germany. Journal of the American Pharmaceutical Association (Scientific ed.). ,vol. 49, pp. 311- 313 ,(1960) , 10.1002/JPS.3030490515
John G. Wagner, Eino Nelson, Per Cent Absorbed Time Plots Derived from Blood Level and/or Urinary Excretion Data Journal of Pharmaceutical Sciences. ,vol. 52, pp. 610- 611 ,(1963) , 10.1002/JPS.2600520629
J. G. WAGNER, C. D. ALWAY, Prediction of Multiple Dose Serum Levels of ‘Lincocin’ from Single Dose Serum Levels When ‘Lincocin’ (As The Hydrochloride) was Administered by Constant Rate Intravenous Infusion Nature. ,vol. 201, pp. 1101- 1103 ,(1964) , 10.1038/2011101A0
Joseph V. Swintosky, Amedeo Bondi, Manford J. Robinson, Sulfaethylthiadiazole IV. Steady State Blood Concentration and Urinary Excretion Data Following Repeated Oral Doses * *Smith Kline & French Laboratories and from Division of Microbiology, Hahnemann School and Hospital, Philadelphia, Pa. Journal of the American Pharmaceutical Association (Scientific ed.). ,vol. 47, pp. 753- 756 ,(1958) , 10.1002/JPS.3030471019
James F. Tait, Sylvia A. S. Tait, Brian Little, Kesho R. Laumas, THE DISAPPEARANCE OF 7-H3-d-ALDOSTERONE IN THE PLASMA OF NORMAL SUBJECTS Journal of Clinical Investigation. ,vol. 40, pp. 72- 80 ,(1961) , 10.1172/JCI104239
R.G. Wiegand, J.D. Buddenhagen, C.J. Endicott, Multiple Dose Excretion Kinetics Journal of Pharmaceutical Sciences. ,vol. 52, pp. 268- 273 ,(1963) , 10.1002/JPS.2600520317
J. D. STEWART, EXCRETION OF SULFANILAMIDE Journal of the American Medical Association. ,vol. 110, pp. 1885- 1887 ,(1938) , 10.1001/JAMA.1938.02790230001001