Composés et compositions pour l'inhibition de l'activité abl1, abl2 et bcr-abl1
作者： Joseph Schoepfer , Paul Manley , Robert Martin Grotzfeld , Xavier Francois Andre Pelle , Andreas Marzinzik
DOI:
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摘要: La presente invention concerne des composes de formule I : dans lesquels Y, Y 1 , 4 5 6 R 2 3 et sont definis le resume l'invention ; aptes a inhiber l'activite BCR-ABL1 mutants associes. L'invention en outre un procede pour la preparation l'invention, preparations pharmaceutiques comprenant tels procedes d'utilisation traitement cancers.
参考文章(38)
D. Fabbro, G. Fendrich, V. Guez, T. Meyer, P. Furet, J. Mestan, J. D. Griffin, P. W. Manley, S. W. Cowan-Jacob, Targeted Therapy with Imatinib: An Exception or a Rule? Inhibitors of Protein Kinases and Protein Phosphates. ,vol. 167, pp. 361- 389 ,(2005) , 10.1007/3-540-26670-4_13
R. R. C. New, Liposomes : a practical approach IRL Press : Oxford University Press. ,(1990)
J. F. W. McOmie, Protective Groups in Organic Chemistry ,(2012)
Jean Jacques, André Collet, Samuel H. Wilen, Enantiomers, Racemates, and Resolutions ,(1981)
Marco Genua, Giuseppe Pandini, Maria Francesca Cassarino, Rosa Linda Messina, Francesco Frasca, c-Abl and insulin receptor signalling. Vitamins and Hormones Series. ,vol. 80, pp. 77- 105 ,(2009) , 10.1016/S0083-6729(08)00604-3
Peter G. M. Wuts, Theodora W. Greene, Protective groups in organic synthesis ,(1981)
Steven A. Rosenberg, Vincent T. DeVita, Samuel Hellman, Cancer : Principles and Practice of Oncology ,(1982)
Jose F Leis, Daniel E Stepan, Peter T Curtin, John M Ford, Bin Peng, Susan Schubach, Brian J Druker, Richard T Maziarz, Central Nervous System Failure in Patients with Chronic Myelogenous Leukemia Lymphoid Blast Crisis and Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Treated with Imatinib (STI-571) Leukemia & Lymphoma. ,vol. 45, pp. 695- 698 ,(2004) , 10.1080/10428190310001625728
G. Wulff, Kohlenhydrate: Chemie der Kohlenhydrate, Monosaccharide und Derivate. Von J. Lehmann. Thieme Taschenlehrbuch der Organischen Chemie B. Georg Thieme Verlag, Stuttgart 1976. I. Aufl., 279 S., 332 Schemata, 10 Tab., DM 24,80. Nachrichten aus Chemie, Technik und Laboratorium. ,vol. 25, pp. 250- 250 ,(1977) , 10.1002/NADC.19770250512
Alessia P. M. Barbagallo, Richard Weldon, Robert Tamayev, Dawang Zhou, Luca Giliberto, Oded Foreman, Luciano D'Adamio, Tyr682 in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo PLoS ONE. ,vol. 5, pp. e15503- ,(2010) , 10.1371/JOURNAL.PONE.0015503