IL-28B rs12979860 polymorphism affect the course of chronic hepatitis and the development of HCC in Egyptian patients with hepatitis C type 4.
作者： AM Attallah , D Omran , M S Marie , Mohamed Abdelrazek , A Salama
DOI: 10.1080/09674845.2018.1489599
关键词: Single-nucleotide polymorphism 、 Gastroenterology 、 Genotype 、 Internal medicine 、 Medicine 、 SNP 、 Interleukin 28B 、 Hepatocellular carcinoma 、 Hepatitis C virus 、 Hepatitis C 、 Cirrhosis
摘要: Background: A single nucleotide polymorphism (SNP) in the interleukin 28B (IL28B) gene may alter trajectory of hepatitis C virus (HCV) chronic infection. Several studies have sought to determine a link between IL28B rs12979860 SNP and development HCV-related hepatocellular carcinoma (HCC), but with variable results, consensus is awaited. We hypothesised that linked HCC patients HCV type 4.Methods: genotyping 300 fibrosis (n = 100), cirrhosis (n = 100) was carried out results were analysed association genotype clinical outcome.Results: In TT carriers, proportions moderate/severe fibrosis, advanced (Child B-C) (50%, 84% 60.2%, respectively) higher (p < 0.05) than CC/CT (4.3%, 46% 23%, respectively). IL-28B significantly progression stages. ...
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