Personality modulates proportions of CD4+ regulatory and effector T cells in response to socially induced stress in a rodent of wild origin.
作者： Marylin Rangassamy , Sara Khaleghparast Athari , Raquel Monclús , Marie-Christophe Boissier , Natacha Bessis
DOI: 10.1016/J.PHYSBEH.2016.09.016
关键词: Personality type 、 Psychology 、 Immunosuppression 、 Personality 、 Elevated plus maze 、 Social stress 、 Immunology 、 Spleen 、 Neophobia 、 Immune system
摘要: Abstract The way how individuals respond to chronic challenges can vary tremendously, and such differences are closely linked personality. few available studies on individual in stress-related immunosuppression non-human mammals have been mainly carried out with laboratory strains. We conducted a study male mound-building mice (Mus spicilegus) of wild origin. distinguished between high (HAN) low anxious/neophobic (LAN) personality types, quantified by subjects' consistent associated behavioral responses repeated elevated plus maze novel object tests. After reaching maturity, parts the subjects were regularly confronted different resident pairs over period 5 days provoke condition social stress, while others used as untreated controls. measured fecal corticosteroid metabolite (FCM) concentrations cellular immune parameters from blood spleen. Socially HAN showed higher increases FCM than LAN, indicating more pronounced physiological stress response former type. experimental group also lower percentages effector T cells (Teff) regulatory (Treg) spleen; latter known for their immunosuppressive activity. Considering ratio Teff/Treg, animals during late experiment stronger shift towards Treg cells, supporting effects chronically levels. Summarizing, our results strongly suggest that immunomodulatory socially induced altered anxiety/neophobia, emphasizing significance shaping challenge.
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