CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP.
作者： Erik M. Schwiebert , Marie E. Egan , Tae-Ho Hwang , Stephanie B. Fulmer , Sandra S. Allen
DOI: 10.1016/S0092-8674(05)80011-X
关键词: Autocrine signalling 、 Cell biology 、 Purinergic receptor 、 Mutant 、 Agonist 、 Chloride channel 、 Cystic fibrosis transmembrane conductance regulator 、 Cell 、 Regulator 、 Biology
摘要: … Several hypotheses that explain how CFTR might control ORCCs include direct protein-… mechanisms whereby CFTR regulates ORCCs. Our results suggest that CFTR regulates ORCCs …
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R. T. Worrell, A. G. Butt, W. H. Cliff, R. A. Frizzell, A volume-sensitive chloride conductance in human colonic cell line T84. American Journal of Physiology-cell Physiology. ,vol. 256, ,(1989) , 10.1152/AJPCELL.1989.256.6.C1111
T.R. Flotte, S.A. Afione, R. Solow, M.L. Drumm, D. Markakis, W.B. Guggino, P.L. Zeitlin, B.J. Carter, Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter Journal of Biological Chemistry. ,vol. 268, pp. 3781- 3790 ,(1993) , 10.1016/S0021-9258(18)53762-5
D A Ausiello, I L Reisin, A G Prat, H F Cantiello, R J Gregory, E H Abraham, J F Amara, The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel. Journal of Biological Chemistry. ,vol. 269, pp. 20584- 20591 ,(1994) , 10.1016/S0021-9258(17)32033-1
S V Ambudkar, P C Maloney, Characterization of phosphate:hexose 6-phosphate antiport in membrane vesicles of Streptococcus lactis Journal of Biological Chemistry. ,vol. 259, pp. 12576- 12585 ,(1984) , 10.1016/S0021-9258(18)90786-6
C.S. Chu, B.C. Trapnell, J.J. Murtagh, J. Moss, W. Dalemans, S. Jallat, A. Mercenier, A. Pavirani, J.P. Lecocq, G.R. Cutting, Variable deletion of exon 9 coding sequences in cystic fibrosis transmembrane conductance regulator gene mRNA transcripts in normal bronchial epithelium. The EMBO Journal. ,vol. 10, pp. 1355- 1363 ,(1991) , 10.1002/J.1460-2075.1991.TB07655.X
E. M. Schwiebert, T. Flotte, G. R. Cutting, W. B. Guggino, Both CFTR and outwardly rectifying chloride channels contribute to cAMP-stimulated whole cell chloride currents. American Journal of Physiology-cell Physiology. ,vol. 266, ,(1994) , 10.1152/AJPCELL.1994.266.5.C1464
J L Gordon, Extracellular ATP: effects, sources and fate. Biochemical Journal. ,vol. 233, pp. 309- 319 ,(1986) , 10.1042/BJ2330309
Johanna M Rommens, Michael C Iannuzzi, Bat-sheva Kerem, Mitchell L Drumm, Georg Melmer, Michael Dean, Richard Rozmahel, Jeffery L Cole, Dara Kennedy, Noriko Hidaka, Martha Zsiga, Manuel Buchwald, Lap-Chee Tsui, John R Riordan, Francis S Collins, Identification of the cystic fibrosis gene: chromosome walking and jumping Science. ,vol. 245, pp. 1059- 1065 ,(1989) , 10.1126/SCIENCE.2772657
S. B. Fulmer, E. M. Schwiebert, M. M. Morales, W. B. Guggino, G. R. Cutting, Two cystic fibrosis transmembrane conductance regulator mutations have different effects on both pulmonary phenotype and regulation of outwardly rectified chloride currents Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 6832- 6836 ,(1995) , 10.1073/PNAS.92.15.6832
Paul M. Quinton, Chloride impermeability in cystic fibrosis. Nature. ,vol. 301, pp. 421- 422 ,(1983) , 10.1038/301421A0