Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism.

摘要: Leishmania and Trypanosoma parasites are responsible for the challenging neglected tropical diseases leishmaniases, Chagas disease, human African trypanosomiasis, which account up to 40,000 deaths annually mainly in developing countries. Current chemotherapy relies on drugs with significant limitations efficacy safety, prompting urgent need explore innovative approaches improve drug discovery pipeline. The unique trypanothione-based redox pathway, is absent hosts, vital all trypanosomatids offers valuable opportunities guide rational development of specific, broad-spectrum anti-trypanosomatid agents. Major efforts focused key metabolic enzymes trypanothione synthetase-amidase reductase, whose inhibition should affect entire pathway and, finally, parasite survival. Herein, we will report comment most recent studies search enzyme inhibitors, underlining promising that have emerged so far drive exploration future successful therapeutic approaches.