In Vitro and In Vivo Modeling of Hydroxypropyl Methylcellulose (HPMC) Matrix Tablet Erosion Under Fasting and Postprandial Status
作者： Benjamin Guiastrennec , Erik Söderlind , Sara Richardson , Alexandra Peric , Martin Bergstrand
DOI: 10.1007/S11095-017-2113-7
关键词: In vivo 、 Chromatography 、 Small intestine 、 Calcium 、 Matrix (chemical analysis) 、 Pharmacology 、 Chemistry 、 In vitro 、 Solubility 、 Hypromellose Derivatives 、 Postprandial
摘要: To develop a model linking in vitro and vivo erosion of extended release tablets under fasting postprandial status. A nonlinear mixed-effects was developed from the profiles four hydroxypropyl methylcellulose (HPMC) matrix studied range experimental conditions. The used to predict HPMC different locations gastrointestinal tract, determined by magnetic marker monitoring. In each segment pH set physiological values mechanical stress estimated USP2 apparatus rotation speed equivalent. Erosion best described Michaelis–Menten type model. maximal rate (VMAX) affected pH, stress, calcium hydrogen phosphate content. amount left at which is half VMAX depended on phosphate. Mechanical for stomach (39.5 rpm), proximal (93.3 rpm) distal (31.1 rpm) small intestine colon (9.99 rpm). silico accurately predicted status can be facilitate future development tablets.
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