Synthetic regulators of ferritin protein nanocage pores and methods of use thereof
作者： Elizabeth Theil
DOI:
关键词: Biology 、 Function (biology) 、 Nanocages 、 Ferritin 、 Demineralization 、 Biochemistry
摘要: The present invention provides synthetic regulators of ferritin pores, and compositions comprising the regulators. function to reduce demineralization rates. are useful for treating inflammatory conditions. also methods further bacterial mini-ferritins; such as antibacterial agents.
lens.org 参考文章(9)
M Ragland, J F Briat, J Gagnon, J P Laulhere, O Massenet, E C Theil, Evidence for conservation of ferritin sequences among plants and animals and for a transit peptide in soybean. Journal of Biological Chemistry. ,vol. 265, pp. 18339- 18344 ,(1990) , 10.1016/S0021-9258(17)44757-0
Elizabeth Theil, Enhancement of iron chelation therapy ,(2003)
S V Torti, E L Kwak, S C Miller, L L Miller, G M Ringold, K B Myambo, A P Young, F M Torti, The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. Journal of Biological Chemistry. ,vol. 263, pp. 12638- 12644 ,(1988) , 10.1016/S0021-9258(18)37801-3
William Breuer, Marieke J. J. Ermers, Pensri Pootrakul, Ayala Abramov, Chaim Hershko, Z. Ioav Cabantchik, Desferrioxamine-chelatable iron, a component of serum non–transferrin-bound iron, used for assessing chelation therapy Blood. ,vol. 97, pp. 792- 798 ,(2001) , 10.1182/BLOOD.V97.3.792
M. J. Grossman, S. M. Hinton, V. Minak-Bernero, C. Slaughter, E. I. Stiefel, Unification of the ferritin family of proteins. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 2419- 2423 ,(1992) , 10.1073/PNAS.89.6.2419
Xiaofeng S. Liu, Leslie D. Patterson, Marvin J. Miller, Elizabeth C. Theil, Peptides Selected for the Protein Nanocage Pores Change the Rate of Iron Recovery from the Ferritin Mineral Journal of Biological Chemistry. ,vol. 282, pp. 31821- 31825 ,(2007) , 10.1074/JBC.C700153200
X. Liu, W. Jin, E. C. Theil, Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 3653- 3658 ,(2003) , 10.1073/PNAS.0636928100
X. Liu, E. C. Theil, Ferritin reactions: Direct identification of the site for the diferric peroxide reaction intermediate Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 8557- 8562 ,(2004) , 10.1073/PNAS.0401146101
C. M. Barnes, E. C. Theil, K. N. Raymond, Iron uptake in ferritin is blocked by binding of [Cr(TREN)(H(2)O)(OH)](2+), a slow dissociating model for [Fe(H(2)O)(6)](2+). Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 5195- 5200 ,(2002) , 10.1073/PNAS.032089399