Multimodal imaging brain markers in early adolescence are linked with a physically active lifestyle

摘要: Abstract The World Health Organization (WHO) promotes physical exercise and a healthy lifestyle as means to improve youth development. However, relationships between brain development are not fully understood. Here, we asked whether – latent mode of covariation underpins the relationship activity, fitness, health measures with multimodal neuroimaging markers. In 50 12-year old school pupils (26 females), acquired whole-brain MRI, characterizing structure, microstructure, function, myelin content, blood perfusion. We also variables measuring objective fitness levels, 7-days body-mass index, heart rate, pressure. Using canonical correlation analysis unravel covariation, independent demographics, school, or socioeconomic status. show that MRI metrics greater involvement in this showed spatially extended patterns across brain. Specifically, global grey matter perfusion, volume, cortical surface area, white extra-neurite density, resting state networks covaried positively reflecting physically active phenotype (high fit, low sedentary individuals). Showing is linked systems-level metrics, these results suggest widespread associations relating several biological processes. These support notion close brain-body underline importance investigating modifiable factors only for but early adolescence. Significance statement An key work, answer following question: How do markers relate young adolescents’ level health? Combining advanced computational approaches, robust lifestyles extended, imaging derived phenotypes. Suggesting wider effect on than previously thought, work underlies studying lifestyle, well other body an effort foster at crucial stage