Nanotopography of biomaterials for controlling cancer cell function

摘要: Abstract: While numerous studies have been conducted to determine the role of nanoparticles in decreasing cancer cell functions, impact material nanotopographies on healthy and carcinoma lung breast functions (such as adhesion, proliferation, apoptosis, morphology vascular endothelial growth factor (VEGF) secretion) has not systematically studied. Recent suggested that cells can recognize respond differently compared flat topographies. However, many these altered both topography chemistry, making it difficult ascertain influence one property other. Studies presented this chapter created materials with similar chemistries but nanoscale topographies, allowing for accurate assessment nanometer features cells. The topographies controlling various observed an increasing number other lines a wide range tissue engineering applications. relevant mechanism(s) behind behaviors nanostructured surfaces well understood, especially Poly(lactic-co-glycolic acid) (PLGA) surfaces, different same demonstrated ability selectively decrease functions. Specifically, present chapter, correlation between surface properties (including topography, wettability, charge, free energy) is discussed. In summary, will report nanotopography-mediated relationship protein adsorption, depicting some possible clues topography-mediated important regenerating keeping cancerous from returning after or tumor resection.