Development of a prognostic signature for esophageal cancer based on nine immune related genes.
作者： Guoren Zhou , Zhi Zhang , Lei Sun , Ying Fang , Jinjun Ye
DOI: 10.1186/S12885-021-07813-9
关键词: Esophageal cancer 、 Gene 、 Transcription factor 、 Surgical oncology 、 Immune system 、 IRGs 、 DKK1 、 Cancer research 、 Biology 、 Cytotoxic T cell
摘要: Function of the immune system is correlated with prognosis tumor. The effect microenvironment on esophageal cancer (EC) development has not been fully investigated. This study aimed to explore a prognostic model based immune-related genes (IRGs) for EC. We obtained RNA-seq dataset and clinical information EC from Cancer Genome Atlas (TCGA). identified 247 upregulated IRGs 56 downregulated IRGs. Pathway analysis revealed that most differentially expressed were enriched in Cytokine-cytokine receptor interaction. further screened 13 survival-related constructed regulatory networks involving related transcription factors (TFs). Finally, was 9 (HSPA6, S100A12, CACYBP, NOS2, DKK1, OSM, STC2, NGPTL3 NR2F2) by multivariate Cox regression analysis. patients classified into two subgroups different outcomes. When adjusted factors, this verified as an independent predictor, which performed accurately prediction. Next, M0 M2 macrophages activated mast cells significantly high-risk group, while CD8 T (Tregs) low-risk group. Prognosis signature nine developed.
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