Anti-obesity effect of two different levels of dehydroepiandrosterone in lean and obese middle-aged female Zucker rats.

摘要: Dehydroepiandrosterone has previously been shown to prevent weight gain in growing lean and obese mice rats. In the present study, female Zucker rats were treated with either 0.6 or 1.0 percent DHEA diet from 8 until 14 months of age. rats, prevented resulted significant loss compared initial body weight. Control had a gain. Both lost over experimental period while control gained Food intake DHEA-treated was lowered but similar that all groups. serum insulin levels both relative elevated hepatic G6PD activity Hepatic malic enzyme by treatment Adipose tissue weights substantially versus their These data indicate adult an anti-obesity effect.