Mapping the coevolution, leadership and financing of research on viral vectors, RNAi, CRSPR/Cas9 and other genomic editing technologies

摘要: In the present investigation, we set out to determine and compare evolution of research on viral vectors, RNAi genomic editing platforms as well profile main institutions funding agencies. A search papers vectors RNAi, CRISPR/Cas, TALENs, ZFNs meganucleases was carried in Web Science. citation network 16,746 constructed. An analysis clustering combined with text mining performed. case a long term process incremental innovation which clusters are organized around specific improvements clinical relevance identified. The most influential investigations were conducted United States European Union where funders government trajectory included related study biological phenomenon its use functional genomics, biomedicine pest control. British philanthropic organization US pharmaceutical company played key role development basic application respectively, addition agencies academic institutions. CRISPR/Cas research, science discoveries led technical improvements, these two turn provided information required for biomedical, agricultural, livestock industrial applications. exhibits geopolitical division investigation efforts between US, producer China increasingly leading applied research. foundations stages Our results reflect change model financing emergence scientific superpower, implications applications technologies.