Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer.

作者: Jeong Eon Lee , Hee Joung Kim , Ji Yeon Bae , Seok Won Kim , Joon-Suk Park

DOI: 10.1186/1471-2407-5-154

关键词: CarcinogenesisCell cultureMorphogenesisBiologyPathologyCancer researchStem cellCancerSurgical oncologyPrecursor cellImmunohistochemistry

摘要: Background Neogenin is expressed in cap cells that have been suggested to be mammary stem or precursor cells. Neogenin known play an important role morphogenesis; however its relationship tumorigenesis remains elucidated.

参考文章(16)
Seok Hyun Kim, Kyung Sun Kang, G. Kong, James E. Trosko, Yong Soon Lee, Chia Cheng Chang, Joon Suk Park, Sung Hoon Kim, Dong Young Noh, Gene expression analysis in SV40-immortalized human breast luminal epithelial cells with stem cell characteristics using a cDNA microarray. International Journal of Oncology. ,vol. 24, pp. 1545- 1558 ,(2004) , 10.3892/IJO.24.6.1545
Charlotte Schubert, Breaking away from the breast Nature Medicine. ,vol. 9, pp. 392- 392 ,(2003) , 10.1038/NM0403-392
Gary B. Silberstein, Postnatal mammary gland morphogenesis. Microscopy Research and Technique. ,vol. 52, pp. 155- 162 ,(2001) , 10.1002/1097-0029(20010115)52:2<155::AID-JEMT1001>3.0.CO;2-P
Jeffrey A Meyerhardt, A Thomas Look, Sandra H Bigner, Eric R Fearon, Identification and characterization of neogenin, a DCC -related gene Oncogene. ,vol. 14, pp. 1129- 1136 ,(1997) , 10.1038/SJ.ONC.1200935
Karpagam Srinivasan, Phyllis Strickland, Ana Valdes, Grace C Shin, Lindsay Hinck, Netrin-1/Neogenin Interaction Stabilizes Multipotent Progenitor Cap Cells during Mammary Gland Morphogenesis Developmental Cell. ,vol. 4, pp. 371- 382 ,(2003) , 10.1016/S1534-5807(03)00054-6
James M. Williams, Charles W. Daniel, Mammary ductal elongation: Differentiation of myoepithelium and basal lamina during branching morphogenesis Developmental Biology. ,vol. 97, pp. 274- 290 ,(1983) , 10.1016/0012-1606(83)90086-6
Kazuko Keino-Masu, Masayuki Masu, Lindsay Hinck, E.David Leonardo, Shirley S.-Y Chan, Joseph G Culotti, Marc Tessier-Lavigne, Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor Cell. ,vol. 87, pp. 175- 185 ,(1996) , 10.1016/S0092-8674(00)81336-7
Anna Sapino, Luigia Macri, Patrizia Gugliotta, Donatella Pacchioni, Yong-Jian Liu, Daniel Medina, Gianni Bussolati, Immunophenotypic properties and estrogen dependency of budding cell structures in the developing mouse mammary gland Differentiation. ,vol. 55, pp. 13- 18 ,(1993) , 10.1111/J.1432-0436.1993.TB00028.X
Euan M. Slorach, Zena Werb, Epithelial morphogenesis: Netrin comes to a sticky and terminal end. Current Biology. ,vol. 13, ,(2003) , 10.1016/S0960-9822(03)00411-1
Chien-Yuan Kao, Koichiro Nomata, Cory S. Oakley, Clifford W. Welsch, Chia-Cheng Chang, Two types of normal human breast epithelial cells derived from reduction mammoplasty: phenotypic characterization and response to SV40 transfection Carcinogenesis. ,vol. 16, pp. 531- 538 ,(1995) , 10.1093/CARCIN/16.3.531