Effects of early undernutrition on kinetic parameters of brain acetylcholinesterase from adult rats.
作者： Tatiana Emanuelli , J.B.T. Rocha , Maria E. Pereira
DOI:
关键词: Internal medicine 、 Offspring 、 Hippocampus (mythology) 、 Weaning 、 Acetylcholinesterase 、 Hypothalamus 、 Striatum 、 Aché 、 Endocrinology 、 Biology 、 Cerebellum
摘要: The effects of undernutrition during early life on acetylcholinesterase (AChE) specific activity cerebellum, hippocampus, hypothalamus and striatum were examined in rehabilitated adults rats. Undernourished rats raised by dams maintained a restricted food scheme from pup birth to weaning (day 31). offspring schedule until day 38 when they started have free access 70-80 days age. Control which had food. results showed that malnutrition caused significant increase AChE cerebellum (about 20%), 40%), 30%). No changes found the hippocampus. Undernutrition Vmax compared control group without Km both striatum. These suggest concentration does not affect affinity enzyme for substrate.
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researchgate.net 参考文章(17)
Ramiro Villescas, Rosemarie Ostwald, Hiromi Morimoto, Edward L. Bennett, Effects of Neonatal Undernutrition and Cold Stress on Behavior and Biochemical Brain Parameters in Rats Journal of Nutrition. ,vol. 111, pp. 1103- 1110 ,(1981) , 10.1093/JN/111.6.1103
Myron Winick, Adele Noble, Cellular response in rats during malnutrition at various ages. Journal of Nutrition. ,vol. 89, pp. 300- 306 ,(1966) , 10.1093/JN/89.3.300
George L. Ellman, K.Diane Courtney, Valentino Andres, Robert M. Featherstone, A new and rapid colorimetric determination of acetylcholinesterase activity Biochemical Pharmacology. ,vol. 7, pp. 88- 95 ,(1961) , 10.1016/0006-2952(61)90145-9
R.C. Wiggins, Gregory Fuller, S.J. Enna, Undernutrition and the development of brain neurotransmitter systems Life Sciences. ,vol. 35, pp. 2085- 2094 ,(1984) , 10.1016/0024-3205(84)90507-1
C. D. Eckhert, R. H. Barnes, D. A. Levitsky, Regional changes in rat brain choline acetyltransferase and acetylcholinesterase activity resulting from undernutrition imposed during different periods of development. Journal of Neurochemistry. ,vol. 27, pp. 277- 283 ,(1976) , 10.1111/J.1471-4159.1976.TB01576.X
B.P.F. Adlard, John Dobbing, Elevated acetylcholinesterase activity in adult rat brain after undernutrition in early life. Brain Research. ,vol. 30, pp. 198- 199 ,(1971) , 10.1016/0006-8993(71)90015-1
Curtis Eckhert, Richard H. Barnes, David A. Levitsky, The effect of protein-energy undernutrition induced during the period of suckling on cholinergic enzyme activity in the rat brain stem. Brain Research. ,vol. 101, pp. 372- 377 ,(1976) , 10.1016/0006-8993(76)90279-1
Linda S. Crnic, Effects of nutrition and environment on brain biochemistry and behavior Developmental Psychobiology. ,vol. 16, pp. 129- 145 ,(1983) , 10.1002/DEV.420160206
Joao BT Rocha, Deusa Vendite, None, Effects of undernutrition and handling during suckling on shuttle avoidance and footshock escape behavior and on plasma glucose levels of young rats Developmental Psychobiology. ,vol. 23, pp. 157- 168 ,(1990) , 10.1002/DEV.420230206
Helen Abbey, Evelyn Howard, Statistical procedure in developmental studies on species with multiple offspring Developmental Psychobiology. ,vol. 6, pp. 329- 335 ,(1973) , 10.1002/DEV.420060406