Intra-vascular blood velocity and volumetric flow rate calculated from dynamic 4D CT angiography using a time of flight technique

摘要: We examine a time of flight (TOF) approach for the analysis contrast enhanced 4D volumetric CT angiography scans to derive and display blood velocity in arteries. Software was written divide vessels into series cross sections track bolus TOF along central vessel axis, which defined by user, from source data. Time density curves at each section were fit with quadratic, Gaussian, gamma variate functions determine peak (TTP). A straight line used plot TTP versus path length all three slope calculate intraluminal velocity. validated simulated square channel non-pulsatile flow phantom prior calculation major cerebral arteries 8 normal patients. The algorithm correctly calculates intra-luminal fluid eight conditions where quadratic used. Across conditions, phantoms vivo, success calculations depended strongly on having sufficiently long make measurements avoiding venous contamination. Total brain approximately 17 % 5 L cardiac output. technique explored vivo patient subclavian steal syndrome, pulmonary iliac artery clinical Intravascular may be calculated using approach.