Cue-Induced Cocaine Craving: Neuroanatomical Specificity for Drug Users and Drug Stimuli

摘要: OBJECTIVE: Cocaine-related cues have been hypothesized to perpetuate drug abuse by inducing a craving response that prompts drug-seeking behavior. However, the mechanisms, underlying neuroanatomy, and specificity of this neuroanatomy are not yet fully understood. METHOD: To address these issues, experienced cocaine users (N=17) comparison subjects (N=14) underwent functional magnetic resonance imaging while viewing three separate films portrayed 1 ) individuals smoking crack cocaine, 2) outdoor nature scenes, 3) explicit sexual content. Candidate sites were identified as those showed significant activation in when film. These then required show significantly greater contrasted with film (population specificity) (content specificity). RESULTS: Brain regions satisfied criteria largely left lateralized included ...