Combination of cytoplasmic and nuclear girdin expression is an independent prognosis factor of breast cancer.
作者： Huikun Zhang , Feng Yu , Fengxia Qin , Ying Shao , Wei Chong
关键词: Breast cancer 、 Prognostic factor 、 Metastasis 、 Biology 、 Chromatin 、 Cytoplasm 、 Human breast 、 Nuclear localization sequence 、 Cancer research 、 Subcellular distribution
摘要: Girdin is an actin-binding protein playing key roles in the development of various carcinomas. Although online tools have predicted nuclear localization girdin with a high probability, convincing proof has rarely been provided until now. The purpose this study was to discover girdin's precise subcellular distribution and potential prognostic value corresponding its localization. detected human breast cancer cell line >800 samples tissue by clinical pathologic analysis. In study, we discovered for first time that could attach chromatin interact topoisomerase-IIα nucleus. Cytoplasmic exhibited different prognosis cancer: cytoplasmic expression independent factor progression-free survival (PFS), whereas overall (OS). More important, combination both OS PFS. conclusion, our research results strongly recommend analysis prediction cancer.-Zhang, H., Yu, F., Qin, Shao, Y., Chong, W., Guo, Z., Liu, X., Fu, L., Gu, Ma, Y. Combination cancer.
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