RNA modifications in brain tumorigenesis.
作者： Albert Z. Huang , Alberto Delaidelli , Poul H. Sorensen
DOI: 10.1186/S40478-020-00941-6
关键词: RNA 、 Polyadenylation 、 Biology 、 Cell growth 、 Carcinogenesis 、 Cell biology 、 Alternative splicing 、 Gene expression 、 Gene isoform 、 Glioma
摘要: RNA modifications are emerging as critical regulators in cancer biology, thanks to their ability influence gene expression and the predominant protein isoforms expressed during cell proliferation, migration, other pro-oncogenic properties. The reversibility dynamic nature of post-transcriptional allow cells quickly adapt microenvironmental changes. Recent literature has revealed that deregulation can promote a plethora developmental diseases, including tumorigenesis. In this review, we will focus on four key which have been identified contributors pathogenesis brain tumors: m6A, alternative polyadenylation, splicing adenosine inosine modifications. addition role tumor progression, also discuss potential opportunities target these processes improve dismal prognosis for tumors.
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