Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy
作者： Yao Di , Yun-Ling He , Tong Zhao , Xin Huang , Kui-Wu Wu
DOI: 10.2119/MOLMED.2015.00038
关键词: Mitophagy 、 Ischemia 、 Necrosis 、 Middle cerebral artery 、 Reperfusion injury 、 Mitochondrion 、 Pharmacology 、 Anesthesia 、 Brain ischemia 、 Medicine 、 Neuroprotection
摘要: The treatment of stroke is limited by a short therapeutic window and lack effective clinical drugs. Methylene blue (MB) has been used in laboratories clinics since the 1890s. Few studies have reported neuroprotective role MB cerebral ischemia-reperfusion injury. However, whether how protects against acute ischemia (ACI) injury was unclear. In this study, we investigated effect on revealed that protected ACI augmenting mitophagy. Using rat middle artery occlusion (MCAO) model, demonstrated improved neurological function reduced infarct volume necrosis after These improvements depended mitochondrial structure function. caused disorder disintegration structure, while ameliorated destruction mitochondria. addition, mitophagy inhibited at 24 h augmented an oxygen-glucose deprivation (OGD) model vitro, further elevation membrane potential (MMP) under OGD conditions mediated contrast, exacerbating decline MMP during abolished MB-induced activation Taken together, promotes maintaining relatively high level, which contributes to decrease improvement function, thereby protecting
biomedcentral.com
springer.com
sci-hub.se 参考文章(53)
Willem Flameng, Marcel Borgers, Willem Daenen, Georges Stalpaert, Ultrastructural and cytochemical correlates of myocardial protection by cardiac hypothermia in man The Journal of Thoracic and Cardiovascular Surgery. ,vol. 79, pp. 413- 424 ,(1980) , 10.1016/S0022-5223(19)37950-4
Michael J. Kelner, Richard Bagnell, Braden Hale, Nicholas M. Alexander, Potential of methylene blue to block oxygen radical generation in reperfusion injury. Basic life sciences. ,vol. 49, pp. 895- 898 ,(1988) , 10.1007/978-1-4684-5568-7_146
Yi Wen, Wenjun Li, Ethan C. Poteet, Luokun Xie, Cong Tan, Liang-Jun Yan, Xiaohua Ju, Ran Liu, Hai Qian, Marian A. Marvin, Matthew S. Goldberg, Hua She, Zixu Mao, James W. Simpkins, Shao-Hua Yang, Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection Journal of Biological Chemistry. ,vol. 286, pp. 16504- 16515 ,(2011) , 10.1074/JBC.M110.208447
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai, Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering PLoS Genetics. ,vol. 10, pp. e1004861- ,(2014) , 10.1371/JOURNAL.PGEN.1004861
M. A. Bin-Umer, J. E. McLaughlin, M. S. Butterly, S. McCormick, N. E. Tumer, Elimination of damaged mitochondria through mitophagy reduces mitochondrial oxidative stress and increases tolerance to trichothecenes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 11798- 11803 ,(2014) , 10.1073/PNAS.1403145111
Yusuke Kurihara, Tomotake Kanki, Yoshimasa Aoki, Yuko Hirota, Tetsu Saigusa, Takeshi Uchiumi, Dongchon Kang, Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast Journal of Biological Chemistry. ,vol. 287, pp. 3265- 3272 ,(2012) , 10.1074/JBC.M111.280156
S Y Kim, M S Shim, K-Y Kim, R N Weinreb, L A Wheeler, W-K Ju, Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury Cell Death and Disease. ,vol. 5, ,(2017) , 10.1038/CDDIS.2014.80
Stephen A Back, Andrew Craig, Robert J Kayton, Ning Ling Luo, Charles K Meshul, Natalie Allcock, Robert Fern, None, Hypoxia-ischemia preferentially triggers glutamate depletion from oligodendroglia and axons in perinatal cerebral white matter. Journal of Cerebral Blood Flow and Metabolism. ,vol. 27, pp. 334- 347 ,(2007) , 10.1038/SJ.JCBFM.9600344
Hao Wu, Danfeng Xue, Guo Chen, Zhe Han, Li Huang, Chongzhuo Zhu, Xiaohui Wang, Haijing Jin, Jun Wang, Yushan Zhu, Lei Liu, Quan Chen, The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy Autophagy. ,vol. 10, pp. 1712- 1725 ,(2014) , 10.4161/AUTO.29568
Yelena K. Baskin, W.Dalton Dietrich, Edward J. Green, Two effective behavioral tasks for evaluating sensorimotor dysfunction following traumatic brain injury in mice. Journal of Neuroscience Methods. ,vol. 129, pp. 87- 93 ,(2003) , 10.1016/S0165-0270(03)00212-7