Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia.

摘要: Hispanic children have a higher incidence of acute lymphoblastic leukemia (ALL) than non-Hispanic whites but tend to be diagnosed at older ages. In genome-wide association studies, Native American ancestry and polymorphisms in six genes been associated with ALL risk. multivariable regression models, we investigated whether genomic ancestry, inherited risk SNPs, or acquired somatic alterations were differences age diagnosis B-cell ALL. Genome-wide array data used estimate each participant's percent membership the three ancestral populations: American, African, European. Each 20% increase European was month younger (95% CI = 0.36–11.6 months, P = 0.037). Correspondingly, six-month (P = 0.037). Both TEL-AML1 translocation high-hyperdiploidy (24.4 P = 2.0 x 10−4 12.4 P = 0.011, respectively), while CDKN2A IKZF1 deletions (19.7 P = 7.0 18.1 P = 0.012, respectively). No associations observed for RAS mutation, PAX5 deletion known heritable alleles IKZF1, CDKN2A, PIP4K2A, GATA3, ARID5B, CEBPE. Because is improved treatment outcomes ALL, effect on survival may mediated by its diagnosis, proxy, more treatable molecular subtypes Am. J. Hematol. 89:721–725, 2014. © 2014 Wiley Periodicals, Inc.