Inducible MicroRNA-223 Down-Regulation Promotes TLR-Triggered IL-6 and IL-1β Production in Macrophages by Targeting STAT3

摘要: MicroRNAs are small non-coding RNA molecules that regulate gene expression by either translational inhibition or mRNA degradation. play pivotal roles in the regulation of both innate and adaptive immune responses, including TLR-triggered inflammatory response. Here we reported microRNA-223 (miR-223) was significantly decreased murine macrophages during activation lipopolysaccharide (LPS) poly (I∶C) stimulation. The inducible miR-223 down-regulation resulted signal transducer activator transcription 3 (STAT3), which is directly targeted miR-223, thus promoting production pro-inflammatory cytokines IL-6 IL-1β, but not TNF-α. Interestingly, found to be a main factor inducing decrease after LPS stimulation, formed positive feedback loop IL-1β. Herein, our findings provide new explanation characterizing molecular mechanism responsible for macrophage activation.