SAMHD1 is a barrier to antimetabolite-based cancer therapies
作者： Sean G. Rudd , Torsten Schaller , Nikolas Herold
DOI: 10.1080/23723556.2017.1287554
关键词: Leukemic Blasts 、 Cytarabine 、 Biology 、 Cancer research 、 Leukemia 、 Myelogenous 、 Cancer cell 、 Antimetabolite 、 Toxicity 、 SAMHD1 、 Immunology
摘要: The outcome of acute myelogenous leukemia (AML) therapy depends on the propensity leukemic blasts to accumulate ara-CTP, active triphosphate cytarabine (ara-C). We identified sterile α motif and HD domain-containing protein 1 (SAMHD1) as an ara-CTPase that protects cancer cells from cytarabine-induced toxicity. Therefore, we propose targeting SAMHD1 a strategy potentiate possibly other antimetabolite-based therapies.
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