Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
作者： Steven M. Reppert , David R. Weaver , Takashi Ebisawa
DOI: 10.1016/0896-6273(94)90055-8
关键词: 5-HT5A receptor 、 Luzindole 、 Melatonin binding 、 Endocrinology 、 Internal medicine 、 GPR50 、 Melatonin 、 Biology 、 Melatonin receptor 、 Melatonergic 、 Melatonin receptor 1A
摘要: The pineal hormone melatonin regulates seasonal reproductive function and modulates circadian rhythms in mammals. We now report the cloning characterization of a high affinity receptor for from sheep human. cDNAs encode proteins that are members newly discovered group within G protein-coupled family. Expression human receptors COS-7 cells results 2-[125I]iodomelatonin binding pharmacological characteristics similar to endogenous receptors. Functional studies NIH 3T3 stably expressing show mammalian is coupled inhibition adenylyl cyclase through pertussis toxin-sensitive mechanism. In situ hybridization mRNA several mammals reveal signals hypophyseal pars tuberalis hypothalamic suprachiasmatic nucleus. cloned likely mediates actions
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sci-hub.se 参考文章(34)
David R. Weaver, M.A.Aryan Namboodiri, Steven M. Reppert, Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain FEBS Letters. ,vol. 228, pp. 123- 127 ,(1988) , 10.1016/0014-5793(88)80599-4
Vincent M Cassone, Effects of melatonin on vertebrate circadian systems. Trends in Neurosciences. ,vol. 13, pp. 457- 464 ,(1990) , 10.1016/0166-2236(90)90099-V
S. Reppert, D. Weaver, S. Rivkees, E. Stopa, Putative melatonin receptors in a human biological clock Science. ,vol. 242, pp. 78- 81 ,(1988) , 10.1126/SCIENCE.2845576
S. A. Rivkees, L. L. Carlson, S. M. Reppert, Guanine nucleotide-binding protein regulation of melatonin receptors in lizard brain. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 3882- 3886 ,(1989) , 10.1073/PNAS.86.10.3882
P. J. Morgan, G. Davidson, W. Lawson, P. Barrett, Both Pertussis Toxin‐Sensitive and Insensitive G‐Proteins Link Melatonin Receptor to Inhibition of Adenylate Cyclase in the Ovine Pars Tuberalis Journal of Neuroendocrinology. ,vol. 2, pp. 773- 776 ,(1990) , 10.1111/J.1365-2826.1990.TB00639.X
K. Petrie, J. V. Conaglen, L. Thompson, K. Chamberlain, Effect of melatonin on jet lag after long haul flights. BMJ. ,vol. 298, pp. 705- 707 ,(1989) , 10.1136/BMJ.298.6675.705
Lars Palm, G�sta Blennow, Lennart Wetterberg, Correction of non-24-hour sleep/wake cycle by melatonin in a blind retarded boy. Annals of Neurology. ,vol. 29, pp. 336- 339 ,(1991) , 10.1002/ANA.410290318
J. ARENDT, M. ALDHOUS, J. ENGLISH, V. MARKS, J. H. ARENDT, M. MARKS, S. FOLKARD, Some effects of jet-lag and their alleviation by melatonin Ergonomics. ,vol. 30, pp. 1379- 1393 ,(1987) , 10.1080/00140138708966031
LINDA L. CARLSON, DAVID R. WEAVER, STEVEN M. REPPERT, Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. Endocrinology. ,vol. 125, pp. 2670- 2676 ,(1989) , 10.1210/ENDO-125-5-2670
Peter J Munson, David Rodbard, None, Ligand: a versatile computerized approach for characterization of ligand-binding systems. Analytical Biochemistry. ,vol. 107, pp. 220- 239 ,(1980) , 10.1016/0003-2697(80)90515-1