A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.
作者： Esther A. Guzmán , Jacob D. Johnson , Patricia A. Linley , Sarath E. Gunasekera , Amy E. Wright
DOI: 10.1007/S10637-010-9422-6
关键词: Cancer 、 Biology 、 Cell growth 、 GSK-3 、 Apoptosis 、 Cancer research 、 Cancer cell 、 Metastasis 、 Kinase 、 Cell biology 、 Pancreatic cancer
摘要: Purpose: Pancreatic cancer is the fourth leading cause of death in United States, and new drugs to treat disease are needed. cells highly metastatic exhibit resistance apoptosis. Small molecules that can restore sensitivity apoptosis or reduce metastasis would have therapeutic potential against this disease. Manzamine A an alkaloid isolated from marine sponges was suspected inhibitory activity mitogen activated kinase (MEK). Because this, effects were studied pancreatic cells. Methods: AsPC-1 treated for 48 h presence various concentrations their phenotype, cytotoxicity, cell invasion susceptibility observed. Results: decreased single formation, abrogated migration restored TRAIL-induced Its mechanism action remains unknown, as manzamine does not inhibit MEK. Conclusions: appears a formerly unrecognized blocking tumor well restoring vitro therefore has be used adjuvant existing therapies.
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