Development of Blood Stage Malaria Vaccines.
作者： Aneesh Vijayan , Chetan E. Chitnis
DOI: 10.1007/978-1-4939-9550-9_15
关键词: Immune mechanisms 、 Immune system 、 Immunology 、 Plasmodium 、 Vaccine efficacy 、 Blood stage 、 Malaria 、 Blood stage malaria 、 Medicine
摘要: The blood stage of the malaria parasite life cycle is responsible for all clinical symptoms malaria. During stage, Plasmodium merozoites invade and multiply within host red cells (RBCs). Here, we review progress made, challenges faced, new strategies available development vaccines. We discuss our current understanding immune responses against stages status various vaccine candidates. then possible paths forward to develop effective This includes a discussion protective mechanisms that can be elicited target parasites, novel delivery systems, immunoassays animal models optimize candidates in preclinical studies, use challenge get an early readout efficacy.
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