Emerging Role of Microglia-Mediated Neuroinflammation in Epilepsy after Subarachnoid Hemorrhage.

摘要: Epilepsy is a common and serious complication of subarachnoid hemorrhage (SAH), giving rise to increased morbidity mortality. It's difficult identify patients at high risk epilepsy the application anti-epileptic drugs (AEDs) following SAH controversial topic. Therefore, it's pressingly needed gain better understanding factors, underlying mechanisms optimization therapeutic strategies for after SAH. Neuroinflammation, characterized by microglial activation release inflammatory cytokines, has drawn growing attention due its influence on with In this review, we discuss factors emphasize critical role microglia. Then how various molecules arising from pathophysiological changes activate specific receptors such as TLR4, NLRP3, RAGE, P2X7R initiate downstream pathways. Additionally, focus significant responses implicated in including neuronal excitotoxicity, disruption blood-brain barrier (BBB) change immune responses. As AEDs seizure prophylaxis remains controversial, regulation neuroinflammation targeting key pathological could be promising method. While appears contribute SAH, more comprehensive experiments their relationships are needed.