How antibiotics kill bacteria: from targets to networks
作者： Michael A. Kohanski , Daniel J. Dwyer , James J. Collins
DOI: 10.1038/NRMICRO2333
关键词: Computational biology 、 Antibiotic drug 、 Biological network 、 Bacteria 、 Direct effects 、 Microbiology 、 Biology 、 Synthetic biology 、 Antibiotics 、 Drug discovery 、 General Immunology and Microbiology
摘要: Antibiotic drug–target interactions, and their respective direct effects, are generally well characterized. By contrast, the bacterial responses to antibiotic drug treatments that contribute to cell death are not as well understood and have proven to be complex as they involve many genetic and biochemical pathways. In this Review, we discuss the multilayered effects of drug–target interactions, including the essential cellular processes that are inhibited by bactericidal antibiotics and the associated cellular response …
cabdirect.org
nature.com
researchgate.net 
sci-hub.se 参考文章(146)
Roger A Garrett, None, The Ribosome, Structure, Function, Antibiotics, and Cellular Interactions ,(2000)
Christopher Walsh, Antibiotics: Actions, Origins, Resistance ,(2003)
John S. Wolfson, David C. Hooper, Quinolone antimicrobial agents american Society for Microbiology. ,(1993)
R Muñoz, A G De La Campa, ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrobial Agents and Chemotherapy. ,vol. 40, pp. 2252- 2257 ,(1996) , 10.1128/AAC.40.10.2252
Michael M. Cox, Myron F. Goodman, Kenneth N. Kreuzer, David J. Sherratt, Steven J. Sandler, Kenneth J. Marians, The importance of repairing stalled replication forks Nature. ,vol. 404, pp. 37- 41 ,(2000) , 10.1038/35003501
Marina V. Rodnina, Tillmann Pape, Wolfgang Wintermeyer, Conformational switch in the decoding region of 16S rRNA during aminoacyl-tRNA selection on the ribosome Nature Structural & Molecular Biology. ,vol. 7, pp. 104- 107 ,(2000) , 10.1038/72364
Curtis T. Keith, Alexis A. Borisy, Brent R. Stockwell, Multicomponent therapeutics for networked systems Nature Reviews Drug Discovery. ,vol. 4, pp. 71- 78 ,(2005) , 10.1038/NRD1609
James A. Imlay, How oxygen damages microbes: oxygen tolerance and obligate anaerobiosis Advances in Microbial Physiology. ,vol. 46, pp. 111- 153 ,(2002) , 10.1016/S0065-2911(02)46003-1
R. Novak, B. Henriques, E. Charpentier, S. Normark, E. Tuomanen, Emergence of vancomycin tolerance in Streptococcus pneumoniae Nature. ,vol. 399, pp. 590- 593 ,(1999) , 10.1038/21202
E W Brunskill, K W Bayles, Identification of LytSR-regulated genes from Staphylococcus aureus. Journal of Bacteriology. ,vol. 178, pp. 5810- 5812 ,(1996) , 10.1128/JB.178.19.5810-5812.1996