Genome Defense Mechanisms in Neurospora and Associated Specialized Proteins

摘要: Neurospora crassa, the filamentous fungus possesses widest array of genome defense mechanisms known to any eukaryotic organism, including a process called repeat-induced point mutation (RIP). RIP is mechanism that hypermutates repetitive DNA sequences; analogous genomic imprinting in mammals. As an impact RIP, many fewer genes multigene families than expected. A methyltransferase homologue, RID was shown be essential for RIP. Recently, variant catalytic subunit translesion polymerase zeta (Polζ ) has been found dominant suppressor phenotype. Meiotic silencing and quelling are two other Neurospora, proteins required these processes have identified through genetic screens.