A New Method for the Fast Solution of Protein-3D-Structures, Combining Experiments and Bioinformatics
作者： Daniel Hoffmann , Volker Schnaible , Stephan Wefing , Mario Albrecht , Daniel Hanisch
DOI: 10.1007/978-3-642-56177-1_6
关键词: Structure validation 、 Protein structure prediction 、 Molecular machine 、 Mass spectrometry 、 Scientific method 、 Computer science 、 Bioinformatics 、 Protein structure 、 Speedup
摘要: Proteins can be considered molecular machines, and protein 3D-structures are key to the understanding of these machines many applications in biotechnology medicine. We developing a method speed up time consuming process structure determination significantly. The closely couples bioinformatics for prediction with fast experiments (chemical cross-linking, specific proteolysis, mass spectrometry) validation. For given protein, iterates over cycles collect more information on structure, finally resulting an Experimentally Validated Model (EVAM) structure.
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