MicroRNAs and nervous system diseases: network insights and computational challenges.
作者： Jianjian Wang , Yuze Cao , Xiaoyu Lu , Tianfeng Wang , Shuang Li
DOI: 10.1093/BIB/BBZ032
关键词: Computational biology 、 Broad spectrum 、 microRNA 、 Mechanism (biology) 、 Computer science
摘要: The nervous system is one of the most complex biological systems, and disease (NSD) a major cause disability mortality. Extensive evidence indicates that numerous dysregulated microRNAs (miRNAs) are involved in broad spectrum NSDs. A comprehensive review miRNA-mediated regulatory will facilitate our understanding miRNA dysregulation mechanisms In this work, we summarized currently available databases on miRNAs NSDs, star NSD miRNAs, width, width distribution sub-categories by reviewing approximately 1000 studies. addition, characterized miRNA-miRNA NSD-NSD interactions from network perspective based miRNA-NSD benchmarking data sets. Furthermore, principles including synergistic regulation modules modules. We also discussed computational challenges for identifying novel Elucidating roles NSDs would not only improve precise mechanism underlying these diseases, but provide insight into development, diagnosis treatment
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