Isoflurane's Effect on Protein Conformation as a Proposed Mechanism for Preconditioning.

摘要: Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect preconditioning. We preincubated human serum albumin isoflurane, dialyzed release agent, and assessed conformation. Susceptibility chemical modification by methylglyoxal nitrophenylacetate was also examined. Isoflurane had persistent effect on An increase in the susceptibility surface residues attended this change Modification isoflurane-treated HSA included intra- intersubunit cross-linking that consequence anesthetic-induced changes multimeric subpopulations. This irreversible represent mechanism for