Duodenal luminal nutrient sensing.
作者： Ivar Rønnestad , Yasutada Akiba , Izumi Kaji , Jonathan D Kaunitz
DOI: 10.1016/J.COPH.2014.07.010
关键词: Taste receptor 、 Digestion 、 Essential nutrient 、 Receptor 、 Duodenum 、 Biochemistry 、 Nutrient 、 Nutrient sensing 、 Biology 、 Intestinal mucosa
摘要: The gastrointestinal mucosa is exposed to numerous chemical substances and microorganisms, including macronutrients, micronutrients, bacteria, endogenous ions, proteins. regulation of mucosal protection, digestion, absorption motility signaled in part by luminal solutes. Therefore, chemosensing an important mechanism enabling the monitor conditions, such as pH, ion concentrations, nutrient quantity, microflora. duodenal shares receptors with lingual taste order detect five basic tastes, addition essential nutrients, unwanted chemicals. recent ‘de-orphanization’ sensing G protein-coupled provides component which senses nutrients. In this review, we will update mechanisms underlying physiological pathological roles sensing, a main focus on mucosa.
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