Dose-related prolongation of hyperbaric tetracaine spinal anesthesia by clonidine in humans

摘要: The effect of clonidine, an alpha 2 agonist, on sensory and motor blockade during spinal anesthesia was studied in 44 ASA physical status I II patients scheduled for orthopedic surgery. were randomly allocated into three groups given 15 mg 0.5% hyperbaric tetracaine (HT), within group (N = 14) 1 ml isotonic saline, 15) 0.5 saline solution clonidine (75 micrograms), III (150 micrograms). Sensory (SB) evaluated by pinprick (MB) according to Bromage's scale. level SB comparable the but duration different. 75 micrograms associated with 25% prolongation at L2 29% grade 3 MB Clonidine 150 prolonged time 72% 96%. Colloid infusion decrease diastolic blood pressure significantly greater compared I. A dose related is demonstrated clonidine.