The brain metabolic signature of visual hallucinations in dementia with Lewy bodies
作者： Leonardo Iaccarino , Arianna Sala , Silvia Paola Caminiti , Roberto Santangelo , Sandro Iannaccone
DOI: 10.1016/J.CORTEX.2018.06.014
关键词: Cortex (anatomy) 、 Dementia with Lewy bodies 、 Neural substrate 、 Cognition 、 Psychology 、 Correlation 、 Visual Hallucination 、 Neurological examination 、 Audiology 、 Neuropsychiatric inventory 、 Experimental and Cognitive Psychology 、 Cognitive neuroscience 、 Neuropsychology and Physiological Psychology
摘要: Abstract Visual hallucinations (VH) are a core clinical feature of dementia with Lewy bodies (DLB), but their specific neural substrate remains elusive. We used 18F-FDG-PET to study the dysfunctional signature VH in group 38 DLB patients (mean age±SD 72.9 ± 7.5) available anamnestic records, cognitive and neurological examination NeuroPsychiatric Inventory assessing VH. tested voxel-wise correlation between hypometabolism NPI scores at whole-group level, then adopting inter-regional analysis explore resting-state networks (RSNs) metabolic connectivity without visual hallucinations, as compared N = 38 age-matched healthy controls (HCs) 71.5 ± 6.9). At we found negative right occipito-temporal cortex (p
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