Enantioselective synthesis of .beta.-amino acids. 4. 1,2 Asymmetric induction in the alkylation of 1-benzoyl-3,6(S)-dimethylperhydropyrimidin-4-one. Preparation of the like and unlike stereoisomers of 2-methyl- and 2-benzyl-3(S)-aminobutanoic acid

关键词: Methyl iodide 、 Amino acid 、 Alkylation 、 Benzyl bromide 、 Asymmetric induction 、 Schiff base 、 Enantioselective synthesis 、 Diastereomer 、 Stereochemistry 、 Chemistry

摘要: The title perhydropyrimidin-4-one (S)-4 was prepared from (S)-3-aminobutanoic acid via the Schiff base (S)-8. This heterocycle alkylated (LDA, methyl iodide, or benzyl bromide) to afford like and unlike diastereomeric products in a 80:20 ratio. Separation hydrolysis (6 N aqueous HCl) of these 5,6-dialkylperhydropyrimidin-4-ones leads free, enantiomerically pure, amino acids 11-14

acs.org 本地加速

acs.org PDF 下载加速

sci-hub.se PDF 下载加速

参考文章(0)

Enantioselective synthesis of .beta.-amino acids. 4. 1,2 Asymmetric induction in the alkylation of 1-benzoyl-3,6(S)-dimethylperhydropyrimidin-4-one. Preparation of the like and unlike stereoisomers of 2-methyl- and 2-benzyl-3(S)-aminobutanoic acid

来源期刊

我的账户

Enantioselective synthesis of .beta.-amino acids. 4. 1,2 Asymmetric induction in the alkylation of 1-benzoyl-3,6(S)-dimethylperhydropyrimidin-4-one. Preparation of the like and unlike stereoisomers of 2-methyl- and 2-benzyl-3(S)-aminobutanoic acid

来源期刊

相似文章 10

我的账户