Folate targeted coated SPIONs as efficient tool for MRI
作者： Cinzia Scialabba , Roberto Puleio , Davide Peddis , Gaspare Varvaro , Pietro Calandra
DOI: 10.1007/S12274-017-1540-4
关键词: Magnetic resonance imaging 、 Nanoparticle 、 Coating 、 Nanotechnology 、 Diagnostic tools 、 Magnetic hyperthermia 、 Folic acid 、 Magnetic nanoparticles 、 Materials science 、 Amphiphile
摘要: The development of more sensitive diagnostic tools allowing an early-stage and highly efficient medical imaging tumors remains a challenge. Magnetic nanoparticles seem to be the contrast agents with highest potential, if properly constructed. Therefore, in this study, hybrid magnetic nanoarchitectures were developed using new amphiphilic inulin-based graft copolymer (INU-LAPEG-FA) as coating material for 10-nm spinel iron oxide (magnetite, Fe3O4) superparamagnetic (SPION). Folic acid (FA) covalently linked order exposed onto nanoparticle surface was chosen targeting agent because folate receptors are upregulated many cancer types. Physicochemical characterization vitro biocompatibility study then performed on prepared nanoparticles. improved properties FA-SPIONs further evaluated nude mice 7-Tesla resonance (MRI). exhibited ability act conventional MRI, providing potential nanoplatform not only tumor diagnosis but also treatment, through delivery anticancer drug or locoregional hyperthermia.
springer.com
core.ac.uk
sci-hub.se 参考文章(40)
Mariano Licciardi, Anna Li Volsi, Carla Sardo, Nicolò Mauro, Gennara Cavallaro, Gaetano Giammona, Inulin-Ethylenediamine Coated SPIONs Magnetoplexes: A Promising Tool for Improving siRNA Delivery Pharmaceutical Research. ,vol. 32, pp. 3674- 3687 ,(2015) , 10.1007/S11095-015-1726-Y
Shahriar Sharifi, Hajar Seyednejad, Sophie Laurent, Fatemeh Atyabi, Amir Ata Saei, Morteza Mahmoudi, Superparamagnetic iron oxide nanoparticles for in vivo molecular and cellular imaging. Contrast Media & Molecular Imaging. ,vol. 10, pp. 329- 355 ,(2015) , 10.1002/CMMI.1638
Jung Soo Suk, Qingguo Xu, Namho Kim, Justin Hanes, Laura M. Ensign, PEGylation as a strategy for improving nanoparticle-based drug and gene delivery Advanced Drug Delivery Reviews. ,vol. 99, pp. 28- 51 ,(2016) , 10.1016/J.ADDR.2015.09.012
Yi-Xiang J. Wang, Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application. Quantitative imaging in medicine and surgery. ,vol. 1, pp. 35- 40 ,(2011) , 10.3978/J.ISSN.2223-4292.2011.08.03
Delia Mandracchia, Nunzio Denora, Massimo Franco, Giovanna Pitarresi, Gaetano Giammona, Giuseppe Trapani, New Biodegradable Hydrogels Based on Inulin and α,β-Polyaspartylhydrazide Designed for Colonic Drug Delivery: In Vitro Release of Glutathione and Oxytocin. Journal of Biomaterials Science-polymer Edition. ,vol. 22, pp. 313- 328 ,(2011) , 10.1163/092050609X12609582084086
N. Mauro, S. Campora, C. Scialabba, G. Adamo, M. Licciardi, G. Ghersi, G. Giammona, Self-organized environment-sensitive inulin–doxorubicin conjugate with a selective cytotoxic effect towards cancer cells RSC Advances. ,vol. 5, pp. 32421- 32430 ,(2015) , 10.1039/C5RA00287G
Yu. G. Asadov, Yu. I. Alyev, K. M. Jafarov, X-ray diffraction study of compounds in the Ag2S-Cu2S system Inorganic Materials. ,vol. 44, pp. 460- 466 ,(2008) , 10.1134/S0020168508050051
Delia Mandracchia, Giuseppe Tripodo, Andrea Latrofa, Rossella Dorati, Amphiphilic inulin-d-α-tocopherol succinate (INVITE) bioconjugates for biomedical applications Carbohydrate Polymers. ,vol. 103, pp. 46- 54 ,(2014) , 10.1016/J.CARBPOL.2013.11.056
Grant L. Zwicke, G. Ali Mansoori, Constance J. Jeffery, Utilizing the folate receptor for active targeting of cancer nanotherapeutics Nano Reviews. ,vol. 3, pp. 18496- ,(2012) , 10.3402/NANO.V3I0.18496
Catherine Cecilia Berry, Stephen Wells, Stuart Charles, Gregor Aitchison, Adam S.G. Curtis, Cell response to dextran-derivatised iron oxide nanoparticles post internalisation Biomaterials. ,vol. 25, pp. 5405- 5413 ,(2004) , 10.1016/J.BIOMATERIALS.2003.12.046