Targeting ligand-functionalized photothermal scaffolds for cancer cell capture and in situ ablation

摘要: Scaffolds have been explored as a useful carrier to deliver efficient photothermal conversion agents for localized therapy applications because they can confine the in designated regions. However, cell capture by porous structures cannot discriminate between cancer cells and normal cells. In this study, folic acid (FA) typical targeting ligand was introduced into scaffolds. Poly-l-lysine mixed with gelatin increase amino side groups FA incorporation. By changing poly-l-lysine amount, number of free scaffolds could be controlled. After reaction activated FA, composite incorporated different amounts were prepared. Cell culture results showed that FA-functionalized efficiently folate-positive cervical compared The efficiency increased amount Furthermore, killed during near-infrared laser irradiation. indicated had good ability excellent ablation efficacy, which may provide information design multifunctional capacity ability.