Friedel-Crafts acylation of W(CO)5-complexes of azaferrocenes
作者： Konrad Kowalski , Janusz Zakrzewski , Lucjan Jerzykiewicz
DOI: 10.1016/J.JORGANCHEM.2004.11.054
关键词: Chemistry 、 Moiety 、 Acetic anhydride 、 Nitrogen 、 Dichloromethane 、 Medicinal chemistry 、 Acylation 、 Lone pair 、 Friedel–Crafts reaction 、 Organic chemistry 、 Aluminium chloride
摘要: Abstract Blocking of the lone pair electrons on nitrogen in azaferrocene by co-ordination to W(CO)5 moiety enables Friedel-Crafts acylation this heteroferrocene. W(CO)5-complexes and 2,5-dimethylazaferrocene react with acetyl- propionyl chloride or acetic anhydride presence aluminium dichloromethane at r.t. give 1′-acylazaferrocenes 10–50% isolated yields. The low yields presumably result from instability products reaction medium. X-ray structure complex 1′-acetylazaferrocene has been determined.
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