作者: Jaquette Liljencrantz , HÃ¥kan Olausson
关键词: Sensory system 、 Analgesic effect 、 Afferent 、 Tactile Allodynia 、 Psychophysics 、 Electrophysiology 、 Psychology 、 Neuroscience 、 Light touch 、 Neuropathic pain
摘要: In humans converging evidence indicates that affective aspects of touch are signaled by low threshold mechanoreceptive C tactile (CT) afferents. Analyses electrophysiological recordings, psychophysical studies in denervated subjects, and functional brain imaging, all indicate CT primary afferents contribute to pleasant provide an important sensory underpinning social behavior. Considering both these gentle skin-to-skin contact, we have put forward a framework within which consider afferent coding properties pathways—the hypothesis. Recent from mice suggests CTs, when activated, may analgesic or anxiolytic effects. However, neuropathic pain conditions, light can elicit unpleasant sensations, so called allodynia. humans, allodynia is associated with reduced mediated hedonic processing suggesting loss the normally effect signaling. We thus propose contribution mainly through their inhibiting role.