Tactile C fibers and their contributions to pleasant sensations and to tactile allodynia.

作者: Jaquette Liljencrantz , HÃ¥kan Olausson

DOI: 10.3389/FNBEH.2014.00037

关键词: Sensory systemAnalgesic effectAfferentTactile AllodyniaPsychophysicsElectrophysiologyPsychologyNeuroscienceLight touchNeuropathic pain

摘要: In humans converging evidence indicates that affective aspects of touch are signaled by low threshold mechanoreceptive C tactile (CT) afferents. Analyses electrophysiological recordings, psychophysical studies in denervated subjects, and functional brain imaging, all indicate CT primary afferents contribute to pleasant provide an important sensory underpinning social behavior. Considering both these gentle skin-to-skin contact, we have put forward a framework within which consider afferent coding properties pathways—the hypothesis. Recent from mice suggests CTs, when activated, may analgesic or anxiolytic effects. However, neuropathic pain conditions, light can elicit unpleasant sensations, so called allodynia. humans, allodynia is associated with reduced mediated hedonic processing suggesting loss the normally effect signaling. We thus propose contribution mainly through their inhibiting role.

参考文章(49)
Y Lamarre, R Forget, Rapid elbow flexion in the absence of proprioceptive and cutaneous feedback. Human neurobiology. ,vol. 6, pp. 27- 37 ,(1987)
Å. B. Vallbo, H. Olausson, J. Wessberg, Unmyelinated afferents constitute a second system coding tactile stimuli of the human hairy skin. Journal of Neurophysiology. ,vol. 81, pp. 2753- 2763 ,(1999) , 10.1152/JN.1999.81.6.2753
Yan Lu, Edward R. Perl, A Specific Inhibitory Pathway between Substantia Gelatinosa Neurons Receiving Direct C-Fiber Input The Journal of Neuroscience. ,vol. 23, pp. 8752- 8758 ,(2003) , 10.1523/JNEUROSCI.23-25-08752.2003
Johan Wessberg, Håkan Olausson, Katarina Wiklund Fernström, Åke B. Vallbo, Receptive Field Properties of Unmyelinated Tactile Afferents in the Human Skin Journal of Neurophysiology. ,vol. 89, pp. 1567- 1575 ,(2003) , 10.1152/JN.00256.2002
India Morrison, Francis McGlone, Håkan Olausson, Line S Löken, Johan Wessberg, Coding of pleasant touch by unmyelinated afferents in humans Nature Neuroscience. ,vol. 12, pp. 547- 548 ,(2009) , 10.1038/NN.2312
R. S. Johansson, M. Trulsson, K. Å. Olsson, J. H. Abbs, Mechanoreceptive afferent activity in the infraorbital nerve in man during speech and chewing movements. Experimental Brain Research. ,vol. 72, pp. 209- 214 ,(1988) , 10.1007/BF00248519
A. Iggo, Cutaneous mechanoreceptors with afferent C fibres. The Journal of Physiology. ,vol. 152, pp. 337- 353 ,(1960) , 10.1113/JPHYSIOL.1960.SP006491