Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride.

摘要: The indenoisoquinoline analogue 9 of nitidine (1) has been prepared and found to possess significant anticancer activity against L1210 lymphoid leukemia, P388 lymphocytic B16 melanocarcinoma. Analogue 14, which lacks the B ring (1), also synthesized. Compound 14 retains in vitro toxicity associated with but is devoid antileukemic activity. structural factors that may contribute difference biological between two closely related analogues are discussed.