Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats

摘要: Phosphorus directly controls parathyroid hormone (PTH) synthesis and secretion. Serum levels of the novel phosphate-regulating hormone, fibroblast growth factor 23 (FGF23), are positively correlated with hyperphosphatemia in patients chronic renal insufficiency (CRI). We proposed that changes serum PTH FGF23 might be associated phosphorus caused by phosphate binder sevelamer hydrochloride (sevelamer, i.e. crosslinked poly[allylamine hydrochloride]). Rats were fed a diet containing adenine for 4 weeks to establish CRI. Animals then offered either normal or 1 3% 8 continuously, intermittently alternating 2-week periods. Changes phosphorus, calcium, PTH, FGF23, α ,25-dihydroxyvitamin D 3 (1,25(OH) 2 ) monitored over time. Adenine-treated rats developed severe CRI, markedly elevated reduced 1,25(OH) . Continuous treatment suppressed these increases throughout study period. decreased rapidly when treatments commenced recovered once they discontinued. However, began after onset levels. In conclusion, circulating can promptly manipulated through control Moreover, phosphate-binder effectively inhibit elevation levels, as well under conditions