Helicobacter pylori infection is the major risk factor for atrophic gastritis

摘要: Objective : To evaluate the association of both Helicobacter pylori (Hp) infection and advancing age with increased prevalence atrophic gastritis. Methods Two hundred thirty-eight subjects who had no esophagitis, peptic ulcers, or malignancies in upper gastrointestinal tract were divided into three groups according to group A, < 30 yr ; B, 30-49 C, ≥ 50 yr. biopsy specimens obtained from lesser curvature antrum two anterior posterior walls fundus assess degree gastritis histological evidence Hp infection. was evaluated by Giemsa staining serum IgG antibodies. Serum gastrin (SG) pepsinogen (PG) determined radioimmunoassay. Results In all groups, significantly more common Hp-positive subjects, age. Atrophic extremely rare, regardless age, Hp-uninfected patients. SG increased, PG I :II ratio decreased subjects. This trend not apparent Hp-negative Conclusion Our results suggest that is a stronger predictor than for