Thirty Years of Antipsychotic Drug Analysis

摘要: Interest in measurement of psychotropic drugs biological fluids dates back to -1955, soon after the introduction chlorpromazine into psychiatry [1]. It was quickly realized that studies regard its disposition and metabolism, detection urine as a means assessing compliance, would be useful [2]. Early attempts involved UV spectrophotometry colorimetry, with or without prior derivatization [3]. However, it not till GC-ECD applied sufficient sensitivity for plasma achieved [4, 5]. Over years, nitrogen detectors, mass spectrometry (MS) liquid chromatography have been used [6–12]. Basically* strategy has had continuously evolve keep up knowledge about metabolites concerned [13–20].