PPI-G4 Glycodendrimers Upregulate TRAIL-Induced Apoptosis in Chronic Lymphocytic Leukemia Cells.
作者： Ida Franiak-Pietryga , Kinga Ostrowska , Henryk Maciejewski , Dietmar Appelhans , Małgorzata Misiewicz
关键词: Microarray 、 Apoptosis 、 Downregulation and upregulation 、 Tumor necrosis factor alpha 、 Fludarabine 、 Chronic lymphocytic leukemia 、 Leukemia 、 Cancer research 、 Signal transduction 、 Medicine
摘要: Although chronic lymphocytic leukemia (CLL) is the most common adult in Western world, it remains incurable with conventional chemotherapeutic agents. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) an antitumor candidate cancer therapy. This study examines proapoptotic effects of poly(propylene imine) (PPI) glycodendrimers modified maltotriose residues (PPI-G4-OS-Mal-III and PPI-G4-DS-Mal-III) on TNF family CLL cells. The combination understanding signaling pathways associated development a molecular profiling key issue for design personalized approaches to Gene expression determined two-color microarray 8 × 60K. findings indicate that PPI-G4-OS/DS-Mal-III affect gene from TRAIL apoptotic pathway exert strong effect cells comparable fludarabine. Dendrimer-targeted technology may well prove bridge gap between ineffective treatment today effective therapy future.
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