Rapid Feasibility Studies of Tracers for Positron Emission Tomography: High-Resolution PET in Small Animals with Kinetic Analysis:

作者: M. Ingvar , L. Eriksson , G. A. Rogers , S. Stone-Elander , L. Widén

DOI: 10.1038/JCBFM.1991.157

关键词: TRACERRadiochemistryPositronIterative reconstructionNuclear medicineDerivativePositron emission tomographyKinetic analysisPet tracerChemistryIn vivo

摘要: The development of methods for production a radiotracer use in human studies with positron emission tomography (PET) is often time-consuming process optimizing radiolabelling yields and handling procedures. Sometimes the not original drug, but rather derivative unknown vivo pharmacological properties. We have developed fast simple method testing putative new PET tracers small animals. procedure has been validated rats different known kinetic properties ([2-18F]2-fluoro-2-deoxy-d-glucose, [N-methyl-11C]Ro 15-1788, [15O]butanol). tracer concentration arterial blood was continuously measured to obtain brain input function. Following image reconstruction scans, time–activity curves selected regions interest were generated. Estimations CMRglc (1.0 ± 0.2 μmol g−1 min−1), CBF (1.4 0.4 ml min−1) transport rate constants 15-1788 (K1 = 0.44 0.0...

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